evidence-based · integrative research

Where naturopathic tradition meets clinical evidence.

Research-grade breakdowns of peptide science, bioregulators, mitochondrial biology, and metabolic interventions. Every claim traced back to the primary literature, no marketing copy.

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Peptides

The Australian Peptide Research Landscape 2026

A comprehensive reference mapping Australian peptide research in 2026: TGA regulatory framework, major peptide classes, research institutions, compounding rules, and 2024–26 policy shifts.

22 min read·Apr 30, 2026
Bioregulators

Epithalon and Telomere Biology: Khavinson's Research

A practitioner-focused review of epithalon telomere research: the mechanisms proposed by Vladimir Khavinson, what the published animal and human studies actually demonstrate, and how integrative clinicians contextualise this pineal-derived tetrapeptide.

20 min readMar 12, 2026
Peptides

CJC-1295 and Ipamorelin: GHRH and Ghrelin Receptor Synergy

CJC-1295 and Ipamorelin act on different receptor classes (GHRH-R and the ghrelin receptor) to amplify the natural pulsatile growth hormone pulse. This article covers how the two mechanisms complement each other and why the combination produces cleaner GH release than either compound alone.

5 min readMay 19, 2025
Peptides

Research Peptides: The Complete Guide to Mechanisms

A comprehensive reference covering all major categories of research peptides: tissue repair, cognitive enhancement, metabolic regulation, longevity, and mitochondrial function. Covers mechanisms, evidence quality, regulatory status, and cross-category comparisons.

8 min readApr 15, 2025
What we cover

Five research lanes. One editorial standard.

9 articles
Peptides

Therapeutic peptide mechanisms, dosing science, and clinical trial evidence.

19 articles
Metabolic

GLP-1 biology, insulin signalling, and metabolic adaptation research.

12 articles
Bioregulators

Short peptide bioregulators including Selank, Semax, and Epitalon.

8 articles
Mitochondrial

Mitochondria-targeted peptides, NAD+ biology, and cellular energy.

9 articles
Anti-aging

Longevity research, epigenetic clocks, and telomere science.

Recently published
Browse library
functional-testing
The Omega-3 Index: What the Test Measures, and Why the Cardiovascular Trial Evidence Is More Mixed Than It Looks
The Omega-3 Index is a well-validated predictor of cardiovascular risk in observational cohorts. But the randomized trial evidence on whether raising it through supplementation actually prevents cardiovascular events is genuinely mixed: one trial of purified EPA showed a large benefit, while trials of EPA+DHA blends in similar high-risk patients and in the general population did not. This article works through why, trial by trial.
Oct 22, 202612 min read
hormones
Postpartum Thyroiditis: What the New 2026 ATA Guidelines Say About Selenium, Monitoring, and the Natural Course
The American Thyroid Association's 2026 guidelines on thyroid disease in pregnancy and postpartum explicitly advise against routine selenium supplementation to prevent postpartum thyroiditis. This article reviews why selenium looked promising in an earlier small trial, why the stronger evidence since has not held up, and what the guideline recommends instead for monitoring and managing the condition.
Oct 15, 202611 min read
hormones
Graves' Disease and Hyperthyroidism: Naturopathic Evidence Beyond Antithyroid Drugs
An evidence-based naturopathic guide to Graves' disease and autoimmune hyperthyroidism: TSH-receptor antibody pathophysiology, why iodine and kelp must be avoided, the selenium RCT for Graves' orbitopathy, the L-carnitine trial evidence, and the honest limits of bugleweed.
Oct 8, 202612 min read
hormones
PMS and PMDD: What a New Supplement Trial Shows, and What the Stronger Evidence Actually Says
A double-blind trial of a ten-ingredient, manufacturer-funded herbal supplement for premenstrual syndrome reported modest benefits. This article reviews that trial honestly, including its funding and design limits, then compares it against the firmer, better-characterized evidence for Vitex agnus-castus, calcium, and vitamin B6.
Oct 1, 202613 min read
clinical
Curcumin for Depression: What a 2026 Meta-Analysis of 19 Trials Actually Shows
A 2026 systematic review and meta-analysis pooled 19 randomized controlled trials testing curcumin supplementation against placebo for depression and depressive symptoms. The pooled effect was statistically significant, but the authors' own sensitivity analysis found it fragile. This article reviews the numbers, the caveats, and what an honest reading means for naturopathic practice.
Sep 24, 20269 min read
autoimmune
Vitamin D3 for Autoimmune Disease: What a 2026 Meta-Analysis of 27 Trials Actually Shows
A 2026 meta-analysis pooled 27 randomized controlled trials (n=1864) testing vitamin D3 against placebo in people with autoimmune disease. This article reviews what improved, what did not move at all, and what that split means for naturopathic practice.
Sep 17, 20269 min read
Editorial method

Science without the marketing layer.

Every article is built from primary literature, clinical trials, meta-analyses, and peer-reviewed research. We translate the mechanism, not the marketing copy. When evidence is preliminary, conflicting, or absent, we say so explicitly.

Primary sourcesPubMed-indexed studies, clinical trials, systematic reviews.
No marketing copyNo sponsored content, no paid placement, no copy from supplement brands.
Corrections welcomeFactual corrections from clinicians and researchers are reviewed and applied openly.
Read our editorial standards