evidence-based · integrative research

Where naturopathic tradition meets clinical evidence.

Research-grade breakdowns of peptide science, bioregulators, mitochondrial biology, and metabolic interventions. Every claim traced back to the primary literature — no marketing copy.

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Peptides

CJC-1295 and Ipamorelin — the science behind GHRH and ghrelin receptor synergy

CJC-1295 and Ipamorelin act on different receptor classes — GHRH-R and the ghrelin receptor — to amplify the natural pulsatile growth hormone pulse. This article covers how the two mechanisms complement each other and why the combination produces cleaner GH release than either compound alone.

5 min read·May 19, 2025
What we cover

Five research lanes. One editorial standard.

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hormones
Hashimoto's Thyroiditis: A Naturopathic Guide to Root Causes and Therapeutic Protocols
A comprehensive naturopathic guide to Hashimoto's thyroiditis — covering autoimmune pathophysiology, why TSH alone is insufficient, root cause framework including gluten molecular mimicry, intestinal permeability, EBV, selenium RCT evidence, low-dose naltrexone, myo-inositol, and the therapeutic pyramid.
May 20, 202619 min read
Metabolic
Mast Cell Activation Syndrome (MCAS): Naturopathic Assessment and Management
A clinical naturopathic guide to MCAS — covering diagnostic criteria, mediator biology, symptom spectrum including POTS overlap, long-COVID association, and evidence-based management with low-histamine diet, DAO support, quercetin, luteolin, PEA, and vitamin C.
May 13, 202618 min read
Metabolic
GI-MAP Stool Test: A Naturopathic Clinician's Guide to Interpretation
A clinician-facing guide to interpreting the GI-MAP stool test — covering DNA-based methodology, key marker panels (H. pylori, parasites, commensals, opportunistic bacteria, intestinal health markers), naturopathic treatment implications per finding, and when to retest.
May 8, 202619 min read
functional
Liver Detoxification Phases: The Evidence Behind Phase 1 and Phase 2 Biotransformation
Liver biotransformation occurs in two phases: Phase 1 (CYP450 oxidation) and Phase 2 (conjugation reactions). Understanding these pathways informs nutritional support strategies and interpretation of OAT and DUTCH functional testing.
May 7, 202614 min read
Metabolic
The Methylation Cycle: A Naturopathic Guide to MTHFR, Homocysteine, and One-Carbon Metabolism
A complete naturopathic reference covering one-carbon metabolism, MTHFR variants, homocysteine pathophysiology, clinical testing, and evidence-based nutritional support for methylation dysfunction.
May 6, 202614 min read
Mitochondrial
NMN vs NR: Comparing NAD+ Precursors for Longevity and Cellular Health
A research-based comparison of NMN and NR as NAD+ precursors — covering the salvage pathway, Brenner and Yoshino human trial data, bioavailability debate, sublingual NMN, dose protocols, cost in the Australian market, and how to test NAD+ levels.
May 6, 202622 min read
Editorial method

Science without the marketing layer.

Every article is built from primary literature — clinical trials, meta-analyses, and peer-reviewed research. We translate the mechanism, not the marketing copy. When evidence is preliminary, conflicting, or absent, we say so explicitly.

Primary sourcesPubMed-indexed studies, clinical trials, systematic reviews.
No marketing copyNo sponsored content, no paid placement, no copy from supplement brands.
Corrections welcomeFactual corrections from clinicians and researchers are reviewed and applied openly.
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