evidence-based · integrative research

Where naturopathic tradition meets clinical evidence.

Research-grade breakdowns of peptide science, bioregulators, mitochondrial biology, and metabolic interventions. Every claim traced back to the primary literature — no marketing copy.

Editor’s pick
All articles
Peptides

CJC-1295 and Ipamorelin — the science behind GHRH and ghrelin receptor synergy

CJC-1295 and Ipamorelin act on different receptor classes — GHRH-R and the ghrelin receptor — to amplify the natural pulsatile growth hormone pulse. This article covers how the two mechanisms complement each other and why the combination produces cleaner GH release than either compound alone.

5 min read·May 19, 2025
What we cover

Five research lanes. One editorial standard.

Recently published
Browse library
environmental
Long COVID: A Functional Medicine Assessment and Recovery Framework
Long COVID functional medicine assessment covering mitochondrial dysfunction, mast cell activation, microclotting, dysautonomia, and evidence-based recovery strategies.
May 21, 202612 min read
hormones
Hashimoto's Thyroiditis: A Naturopathic Guide to Root Causes and Therapeutic Protocols
A comprehensive naturopathic guide to Hashimoto's thyroiditis — covering autoimmune pathophysiology, why TSH alone is insufficient, root cause framework including gluten molecular mimicry, intestinal permeability, EBV, selenium RCT evidence, low-dose naltrexone, myo-inositol, and the therapeutic pyramid.
May 20, 202619 min read
gut
Histamine Intolerance: DAO, HNMT, and a Functional Diagnostic and Treatment Protocol
A clinical examination of histamine intolerance — distinguishing it from IgE-mediated allergy and mast cell activation syndrome, explaining DAO and HNMT degradation pathways, dietary triggers, the four-week low-histamine elimination and reintroduction protocol, DAO supplementation evidence, and nutritional cofactors.
May 13, 202614 min read
Metabolic
Mast Cell Activation Syndrome (MCAS): Naturopathic Assessment and Management
A clinical naturopathic guide to MCAS — covering diagnostic criteria, mediator biology, symptom spectrum including POTS overlap, long-COVID association, and evidence-based management with low-histamine diet, DAO support, quercetin, luteolin, PEA, and vitamin C.
May 13, 202618 min read
Metabolic
Endometriosis Naturopathic Treatment: Evidence and Protocol
A clinical naturopathic guide to endometriosis: oestrogen dominance, immune dysfunction, and the evidence for dietary, nutraceutical, and functional approaches.
May 12, 202614 min read
Metabolic
GI-MAP Stool Test: A Naturopathic Clinician's Guide to Interpretation
A clinician-facing guide to interpreting the GI-MAP stool test — covering DNA-based methodology, key marker panels (H. pylori, parasites, commensals, opportunistic bacteria, intestinal health markers), naturopathic treatment implications per finding, and when to retest.
May 8, 202619 min read
Editorial method

Science without the marketing layer.

Every article is built from primary literature — clinical trials, meta-analyses, and peer-reviewed research. We translate the mechanism, not the marketing copy. When evidence is preliminary, conflicting, or absent, we say so explicitly.

Primary sourcesPubMed-indexed studies, clinical trials, systematic reviews.
No marketing copyNo sponsored content, no paid placement, no copy from supplement brands.
Corrections welcomeFactual corrections from clinicians and researchers are reviewed and applied openly.
Read our editorial standards